2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-126361
    ZK824190
    		Inhibitor
    ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.
    ZK824190
  • HY-E70226
    Cathepsin S, human
    Cathepsin S, human, is a potent cysteine protease that promotes the degradation of damaged or harmful proteins in the endolysosomal pathway. Cathepsin S, human, is involved in multiple pathological processes, including arthritis, cancer, and cardiovascular disease.
    Cathepsin S, human
  • HY-E70192
    Acetyltrypsin, Bovine pancreas
    Acetyltrypsin, Bovine pancreas is a stable trypsin derivative that can catalyze the hydrolysis of alpha-N-benzoyl-L-argininamide.
    Acetyltrypsin, Bovine pancreas
  • HY-144820
    JO146
    		Inhibitor 98.49%
    JO146 is a Chlamydia trachomatis high temperature requirement A (CtHtrA) protease inhibitor with IC50s of 21.86 and 1.15 μM for CtHtrA and human neutrophil elastase (HNE), respectively. JO146 can be used to inhibits bacterial infections.
    JO146
  • HY-P2942
    Chymotrypsinogen
    Chymotrypsinogen is an inactive precursor of Chymotrypsin (HY-108910). Chymotrypsin is a serine protease produced by the pancreas.
    Chymotrypsinogen
  • HY-161847
    HZ1
    		Inhibitor 99.20%
    Anticancer agent 241 (HZ1) is an orally active first-in-class cyclin-dependent kinase like 3 (CDKL3)-specific inhibitor. Anticancer agent 241 shows a strong tumor-suppressing effect, and has the potential to overcome the resistance of CDK4/6 inhibitor.
    HZ1
  • HY-19303A
    CRA-2059 hydrochloride
    		Inhibitor
    CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ).
    CRA-2059 hydrochloride
  • HY-P2828
    [Des-Pro2]-Bradykinin
    		Inhibitor 99.68%
    [Des-Pro2]-Bradykinin is a protease inhibitor. [Des-Pro2]-Bradykinin prevents the degradation of methionine enkephalin.
    [Des-Pro2]-Bradykinin
  • HY-108285
    (Rac)-Telmesteine
    		Inhibitor 98.0%
    (Rac)-Telmesteine is a protease inhibitor and is thus a suitable enzyme stabilizer extracted from patent WO 2017220302 A1, compound II-1. (Rac)-Telmesteine can be used as an enzyme stabilizer in protease-containing detergents and cleaning agents.
    (Rac)-Telmesteine
  • HY-P5536
    Irucalantide
    		Inhibitor 99.88%
    Irucalantide is kallikrein inhibitor.
    Irucalantide
  • HY-145263A
    VD2173 epimer-1
    		Control
    VD2173 epimer-1 is a racemic mixture of VD2173 (HY-145263).
    VD2173 epimer-1
  • HY-P3150
    Recombinant Proteinase K
    		Agonist
    Recombinant Proteinase K is a serine protease that cleaves the carboxy-terminated peptide bonds of aliphatic and aromatic amino acids. Recombinant Proteinase K can be used to digest proteins and remove contamination from nucleic acid preparations.
    Recombinant Proteinase K
  • HY-P4470
    Phe-Pro-Ala-pNA
    		98.96%
    Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity.
    Phe-Pro-Ala-pNA
  • HY-P4464A
    Ala-Phe-Pro-pNA TFA
    		Substrate 99.85%
    Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA TFA can be used to test tripeptidyl peptidase activity.
    Ala-Phe-Pro-pNA TFA
  • HY-P4243A
    Dansyl-Glu-Gly-Arg-Chloromethylketone TFA
    		Inhibitor 98.45%
    Dansyl-Glu-Gly-Arg-Chloromethylketone TFA is a protease inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone TFA inhibits activated porcine factor IX.
    Dansyl-Glu-Gly-Arg-Chloromethylketone TFA
  • HY-B0190B
    Nafamostat hydrochloride
    		Inhibitor
    Nafamostat hydrochloride, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat hydrochloride has anticancer and antivirus effect. Nafamostat hydrochloride induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat hydrochloride can be used in the development of the pathological thickening of the arterial wall.
    Nafamostat hydrochloride
  • HY-13512R
    Camostat mesylate (Standard)
    		Inhibitor
    Camostat (mesylate) (Standard) is the analytical standard of Camostat (mesylate). This product is intended for research and analytical applications. Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase.
    Camostat mesylate (Standard)
  • HY-137038
    N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride
    		Inhibitor
    N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is an irreversible inhibitor for serine protease, which inhibits trypsin and trypsin-like protease by alkylating histidine residues in their active site. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride inhibits caspase-3, caspase-6 and caspase-7, with IC50s of 12.0, 54.5 and 19.3 μM, respectively. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride induces apoptosis in cell HL-60, and inhibits the decrease in mitochondrial transmembrane potential during apoptosis.
    N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride
  • HY-W004066R
    Ac-Ala-OH (Standard)
    Ac-Ala-OH (Standard) is an analytical standard for Ac-Ala-OH. This product is intended for use in research and analytical applications. Ac-Ala-OH is an endogenous metabolite. Ac-ALA-OH inhibits APEH. Ac-Ala-OH is useful in breast cancer research .
    Ac-Ala-OH (Standard)
  • HY-W783268
    Matriptase-IN-2 free base
    		Inhibitor
    Matriptase-IN-2 free base is a matriptase inhibitor with a Ki of 5 nM. Matriptase-IN-2 has the potential for musculoskeletal system disorder research (WO2011023958A1; compound 432).
    Matriptase-IN-2 free base
Cat. No. Product Name / Synonyms Application Reactivity