2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162653
    CDKL2-IN-1
    		Inhibitor
    CDK-IN-14 (Compound 9) is a potent and selective CDKL2 (Cyclin-dependent kinase-like 2) inhibitor with an IC50 value of 460 nM. CDKL2 is involved in various biological processes such as tumorigenesis, development, and viral infections. CDK-IN-14 serves as a powerful tool for studying the biological functions of CDKL2 and holds promise for research in fields related to cancer, infections, and other diseases.
    CDKL2-IN-1
  • HY-19303A
    CRA-2059 hydrochloride
    		Inhibitor
    CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ).
    CRA-2059 hydrochloride
  • HY-P2828
    [Des-Pro2]-Bradykinin
    		Inhibitor 99.68%
    [Des-Pro2]-Bradykinin is a protease inhibitor. [Des-Pro2]-Bradykinin prevents the degradation of methionine enkephalin.
    [Des-Pro2]-Bradykinin
  • HY-108285
    (Rac)-Telmesteine
    		Inhibitor ≥98.0%
    (Rac)-Telmesteine is a protease inhibitor and is thus a suitable enzyme stabilizer extracted from patent WO 2017220302 A1, compound II-1. (Rac)-Telmesteine can be used as an enzyme stabilizer in protease-containing detergents and cleaning agents.
    (Rac)-Telmesteine
  • HY-P5536
    Irucalantide
    		Inhibitor 99.88%
    Irucalantide is kallikrein inhibitor.
    Irucalantide
  • HY-145263A
    VD2173 epimer-1
    		Control
    VD2173 epimer-1 is a racemic mixture of VD2173 (HY-145263).
    VD2173 epimer-1
  • HY-P3150
    Recombinant Proteinase K
    		Agonist
    Recombinant Proteinase K is a serine protease that cleaves the carboxy-terminated peptide bonds of aliphatic and aromatic amino acids. Recombinant Proteinase K can be used to digest proteins and remove contamination from nucleic acid preparations.
    Recombinant Proteinase K
  • HY-P4470
    Phe-Pro-Ala-pNA
    		98.96%
    Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity.
    Phe-Pro-Ala-pNA
  • HY-P4464A
    Ala-Phe-Pro-pNA TFA
    		Substrate 99.85%
    Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA TFA can be used to test tripeptidyl peptidase activity.
    Ala-Phe-Pro-pNA TFA
  • HY-P4243A
    Dansyl-Glu-Gly-Arg-Chloromethylketone TFA
    		Inhibitor 98.45%
    Dansyl-Glu-Gly-Arg-Chloromethylketone TFA is a protease inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone TFA inhibits activated porcine factor IX.
    Dansyl-Glu-Gly-Arg-Chloromethylketone TFA
  • HY-B0190B
    Nafamostat hydrochloride
    		Inhibitor
    Nafamostat hydrochloride, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat hydrochloride has anticancer and antivirus effect. Nafamostat hydrochloride induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat hydrochloride can be used in the development of the pathological thickening of the arterial wall.
    Nafamostat hydrochloride
  • HY-13512R
    Camostat mesylate (Standard)
    		Inhibitor
    Camostat (mesylate) (Standard) is the analytical standard of Camostat (mesylate). This product is intended for research and analytical applications. Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase.
    Camostat mesylate (Standard)
  • HY-137038
    N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride
    		Inhibitor
    N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is an irreversible inhibitor for serine protease, which inhibits trypsin and trypsin-like protease by alkylating histidine residues in their active site. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride inhibits caspase-3, caspase-6 and caspase-7, with IC50s of 12.0, 54.5 and 19.3 μM, respectively. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride induces apoptosis in cell HL-60, and inhibits the decrease in mitochondrial transmembrane potential during apoptosis.
    N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride
  • HY-W004066R
    Ac-Ala-OH (Standard)
    Ac-Ala-OH (Standard) is an analytical standard for Ac-Ala-OH. This product is intended for use in research and analytical applications. Ac-Ala-OH is an endogenous metabolite. Ac-ALA-OH inhibits APEH. Ac-Ala-OH is useful in breast cancer research .
    Ac-Ala-OH (Standard)
  • HY-W783268
    Matriptase-IN-2 free base
    		Inhibitor
    Matriptase-IN-2 free base is a matriptase inhibitor with a Ki of 5 nM. Matriptase-IN-2 has the potential for musculoskeletal system disorder research (WO2011023958A1; compound 432).
    Matriptase-IN-2 free base
  • HY-122805
    PF-794
    		Inhibitor 99.19%
    PF-794 is a potent, selective and ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC50 of 39 nM. PF-794 shows selective for the TNIK family. PF-794 reduces endogenous p120-catenin phosphorylation in cells. PF-794 can be used for teh study of psychiatric disorders.
    PF-794
  • HY-P990429
    Anti-Hepsin Antibody
    		Inhibitor
    Anti-Hepsin Antibody is a CHO-expressed human antibody that targets Hepcidin. Anti-Hepsin Antibody has huIgG1 heavy chain and huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-Hepcidin/HAMP Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-Hepsin Antibody
  • HY-18234
    Leupeptin
    		Inhibitor
    Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity.
    Leupeptin
  • HY-19820
    NSC45586
    		Inhibitor
    NSC45586 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons.
    NSC45586
  • HY-152846
    Flizasertib
    		Inhibitor
    Flizasertib is a serine/threonine kinase inhibitor.
    Flizasertib
Cat. No. Product Name / Synonyms Application Reactivity